Effect A Dispersant On The Dissolution Of Ferrous Fumarate From Capsule Formulations
The effect of sodium starch glycollate, a dispersant on the dissolution of ferrous fumarate capsules was studied. Ferrous fumarate was formulated into capsules with sodium starch glycollate and the capsules were evaluated (immediately after preparation and after storage at exaggerated conditions of temperature and relative humidity) for physical parameters, disintegration, drug content, and dissolution rate. Marked increase in the dissolution of ferrous fumarate was observed when sodium starch glycollate was included in the capsule formulation. This formulation gave fast and rapid dissolution of ferrous fumarate fulfilling the BP 1999 dissolution requirement.