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Abstract

Effect of additives on release of centperazine from matrix tablets

Author(s): SK Baveja, K VR Rao
Divn. of Pharamaceutics, Department of Pharmaceutical Sciences, Panjab University, Chandigarh-160 014

Correspondence Address:
S K Baveja ivn. of Pharamaceutics, Department of Pharmaceutical Sciences, Panjab University, Chandigarh-160 014

Effect of various additives like purified talc, Aerosil 200, sodium lauryl sulfate (SLS) and sodium chloride of various sieve fractions on the release of centperazine (a liquid freely soluble in polar and non-polar solvents) from carnauba wax matrix tablets was studied. Aerosil 200 and SLS increased the release rate while talc and sodium chloride did not affect it significantly. Particle size of sodium chloride was found to have little effect on release of drug.