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Abstract

Effect Of Cholesterol Content And Surfactant HLB On Vesicle Properties Of Niosomes

Author(s): S Agarwal, Vasudha Bakshi, P Vitta, A. P Raghuram, S Pandey, N Udupa

Effect of cholesterol content on entrapment efficiency and influence of surfactant HLB on the vesicle size has been studied on sorbitan esters vesicles also known as nicsomes prepared using a mechanical shaking technique without sonication. Primaquine phosphate was used as a model drug. Entrapment efficiency increased with Increasing cholesterol content. Mean size of unsonicated niosomes showed a regular increase with increasing HLB from Span 85 (HLB 1.8) to Span 20 (HLB 8.6).