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Abstract

Effect Of Polyvinylpyrrolidone On Physical Characteristics Of Ketoprofen-Loaded Polystryrene Microparticles

Author(s): K.S Rajesh, B.B Bhowmik, B Sa

Ketoprofen-loaded polystyrene microparticles containing variable amount of polyvinylpyrrolidone as a copolymer were prepared by emulsion solvent evaporation method. The effect of polymer combination and initial drug loading on physical characteristics of the microparticles were studied. Although the microparticles were prepared by emulsification using different polymer combinations, the mean diameters were confined within a narrow range. However increase in initial drug loading increased the mean diameters of the microparticles. Polystyrene was found to be highly impermeable to drug release. Incorporation of polyvinylpyrrolidone easily modulated drug release. Mechanism of drug release was found to be a complex one.