Effect Of Selected Binders And Disintergrants On The Dissolution Rate Nimesulide From Tablets
Much variations in the disintegration and dissolution characteristics were observed when the effect of seven commonly used binders namely starch paste, acacia, sucrose, poly vinyl pyrrolidone (PVP), hydroxy propyl methyl cellulose (HPMC), methyl cellulose and gelatin and four disintegrants namely potato starch, micro crystalline cellulose (MCC), pregelatinized starch (PGS) and Primogel on the dissolution rate and other qualities of nimesulide tablets was studied. ANOVA of dissolution efficiency (DE30) values and Duncan's Multiple Range Test were used to compare the performance of various binders and disintegrants. Based on DE30 values the order of performance of binders and HPMC>PVP> sucrose>acacia>starch paste>methyl cellulose>gelatin and that of disintegrants was Primogel>PGS> potato starch>MCC. Tablets formulated employing PVP-potato starch, HPMC-potato starch, starch paste-Primogel, PVP-PGS and PVP-Primogel as binder-disintegrant gave much higher dissolution rate and efficiency values than other, both formulated and commercial. The above tablets also fulfilled all other official requirements.