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Abstract

Effect of temperature on the granule formulation of new antimalarial compounds (80/53) n1-3'-acetyl-4',5'-dihydro-2'-furanyl-n4-(6-methoxy, 8-quinolinyl) 1,4-pentane diamine.

Author(s): AK Dwivedi, D Kulkarni, P Prakash, S Singh
Divn. of Pharmaceutics, Central Drug Research Institute, Lucknow - 226 001

Correspondence Address:
A K Dwivedi Divn. of Pharmaceutics, Central Drug Research Institute, Lucknow - 226 001

The chemical stability of antimalarial compound N1-3'-acetyl-4',5'-dihydro-2'-furanyl-N4-(6-methoxy, 8-quinolinyl)-1,4 pentane diamine (80/53) (I) in the granuale formulation at various temperature was investigated. The order of reaction degradation rate constant were computed by least square linear regression.