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Abstract

Effect Of Ziziphus Jujuba Leaf Extract On Body Weight, Food Intake And Serum Lipid Levels In Sucrose-Induced Obese Rats.

Author(s): M. S Ganachari, Shiv Kumar

Rats were provided with 32% w/v sucrose solution as a supplement to their normal diet for 125 days to induce obesity. The parameters studied include body weight analysis on day 1, 30, 60, 90 and 125; daily food intake and serum lipid levels at the end of treatment. The hydroalcoholic extract of Zizjphus jujuba leaves at the doses of 200, 400 and 600 mg/kg, p.o. given daily for 125 days caused reduction in body weight, daily food intake and serum total cholesterol, LDL-cholesterol, VLDL-cholesterol and triglycerides along with an increase in HDL-cholesterol levels. The results obtained with 400 and 600 mg/kg dose of Ziziphus jujuba extract were significant when compared to sucrose control group. These results suggest that Ziziphus jujuba leaf extract possesses significant weight reducing, hypophagic and hypolipidemic properties in sucrose-induced obese rats.