Effects of cream containing ficus carica L. fruit extract on skin parameters: In vivo evaluation
1Department of Pharmacy, The Islamia University of Bahawalpur, Pakistan 2Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060, Pakistan
A Ali Department of Pharmacy, COMSATS Institute of Information Technology, Abbottabad 22060 Pakistan E‑mail: [email protected]
This study was aimed to investigate the effects of cream containing Ficus carica L. fruit ([Figure 1]) extract on various skin parameters such as skin melanin, erythema, moisture content, trans-epidermal water loss and sebum. For this purpose, formulation with 4% concentrated extract of F. carica fruit and base without extract were developed. Base served as a control. Both base and formulation were applied to the cheeks of human volunteers for 8 weeks to investigate the effects on different skin parameters using non-invasive bioengineering instruments. Formulation decreased the skin melanin, trans-epidermal water loss and skin sebum significantly. Formulation increased the skin hydration significantly and insignificant effects on skin erythema. We concluded that a stable topical cream (w/o emulsion) containing F. carica fruit extract have effects on skin melanin, trans-epidermal loss, hydration values and sebum content and possibly could be used against for hyper pigmentation, acne, freckles and wrinkle.