Enhancement of skin permeation of ibuprofen from ointments and gels by sesame oil, sunflower oil and oleic acid
1 Department of Pharmaceutics, Jeypore College of Pharmacy, Rondapalli, Jeypore-764 002, India 2 Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India
S C Dinda Department of Pharmaceutics, Jeypore College of Pharmacy, Rondapalli, Jeypore-764 002 India E-mail: [email protected]
Several batches of paraffin ointments were prepared and ibuprofen was incorporated into them. Sesame oil, sunflower oil, and oleic acid in different concentrations were incorporated into different batches. Commercial ibuprofen gel was obtained and divided into several batches and different concentrations of sesame oil, sunflower oil, and oleic acid were incorporated into them. The in vitro drug release characteristics through hairless (88 mm) rat skin was carried out by using modified Insertion cell designed in our laboratory. The cell was placed into a borosil beaker containing 50 ml of pH 7.4 phosphate buffer as the diffusion fluid. The beaker was placed over the magnetic stirrer, which was maintained at 37±0.5° to maintain the temperature of diffusion fluid. The released drug content at predetermined time interval was measured using U-V-double beam spectrophotometer at 272 nm. The drug release was raised with increase in oil concentration.