Enhancement of the Solubility of Poorly Water Soluble Drugs through Solid Dispersion: A Comprehensive Review
Department of Pharmaceutical Sciences, IKG Punjab Technical University, Kapurthala-144 603, Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar-143 001, Department of Pharmaceutics, ISF College of Pharmacy, Moga-142001, Department of Pharmaceutics, ASBASJSM College of Pharmacy, Bela, Ropar-140 111, India
Department of Pharmaceutical Sciences, IKG Punjab Technical University, Kapurthala-144 603, India, E-mail: [email protected]
Solubility is an important determinant in drug liberation and hence drug absorption, which plays a key role in oral bioavailability of formulations. The dissolution rate of a drug directly depends upon its solubility. Most of the new drugs have poor water solubility; thereby pose a difficulty in formulating into drug delivery systems. Therefore, solubility enhancement of poorly water soluble drugs is one of the necessary preformulation steps in the pharmaceutical product development research. Solid dispersion is a unique and promising approach for enhancing the dissolution characteristics and oral bioavailability of poorly water-soluble drugs. The present review highlights portrayal of solid dispersions, its types including eutectic mixtures and solid solutions, method of preparation and also the useful carriers for the preparation of solid dispersions. Furthermore, the wide research conducted hitherto on solid dispersions for enhancing solubility of different efficacious drugs, challenges encountered in the development of solid dispersions and recent advancements to overcome its pitfalls have also been elaborated.