Evaluation Of Antiinflammatory And Antihyperalgesic Activity Of Some Novel Monocylic ?-Iactam Compounds In Rats.
Synthesis and evaluation of some novel monocyclic beta-lactam compounds as anti-inflammatory and anti-hyperalgesic agents has been carried out in the present study. Such type of compounds has been reported in literature as human leukocyte elastase (HLE) inhibitors. The compounds were administered orally (15 mg/kg) to rats 30 min before injecting carageenan in the planter aponeurosis. The compounds showed a marked effect on paw edema and associated inflammatory pain. Compound 1 showed antiinflammatory effect even better than indomethacin (10 mg/kg) used as reference standard. These results suggest the need of carrying out further in vitro studies on the mechanism of action, which may be HLE inhibition.