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Abstract
Extractive spectrophotometric method for determination of carvedilol in tablets
Author(s): JK Verma, HA Syed
Department of Chemistry, K. J. Somaiya College of Science and Commerce, Vidyavihar, Mumbai - 400 077, India
Correspondence Address:
J K Verma Department of Chemistry, K. J. Somaiya College of Science and Commerce, Vidyavihar, Mumbai - 400 077 India E-mail: s.h.abbas@sify.com
Department of Chemistry, K. J. Somaiya College of Science and Commerce, Vidyavihar, Mumbai - 400 077, India
Correspondence Address:
J K Verma Department of Chemistry, K. J. Somaiya College of Science and Commerce, Vidyavihar, Mumbai - 400 077 India E-mail: s.h.abbas@sify.com
A sensitive and rapid extractive spectrophotometer method has been developed for the assay of carvedilol in pharmaceutical formulations. The method is based on the formation of a chloroform soluble ion-pair complex between carvedilol and bromocresol green in an acidic medium. The complex shows absorption maximum at 415 nm and the system obeys Beer's law in the concentration range of 5-25 µg/ml. The results obtained by the proposed method were validated statistically and by recovery studies.
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