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Abstract

Extractive Spectrophotometric Method For The Determination Of Clarithromycin

Author(s): Y Srinivasa Rao, V Jitendrababu, K.P.R Chowdary, J.V.L.N Seshagiri Rao

A simple extractive spectrophotometric method has been developed for the estimation of clarithromycin in both pure and pharmaceutical dosage forms. The method is based on the formation of an ion-pair complex of the drug with bromocresol green, which is extracted into chloroform. The absorbance of the chloroform layer is measured at 415 nm against a reagent blank. The method has been statistically evaluated.