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Abstract

Fast Dissolving Rofecoxib Tablets

Author(s): J. K Lalla, H. M Mamania

Inclusion complex of rofecoxib, an NSAlD with β-cyclodextrin using ball milling technique has been prepared and evaluated using DSC. The fast dissolving tablet composition with 25 mg equivalent rofecoxib showed complete release of rofecoxib in 12 min as compared to 20% drug release from the conventional release marketed tablets during the same period. The stability studies conducted as per ICH guidelines at 40° and 75% RH showed insignificant loss in drug content at the end of six months.