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Abstract

Formulation And Dissolution Rate Studies On Dispersible Tablets Of Ibuprofen

Author(s): K. P. R Chowdary, R Hymavathi

Dispersible tablets of ibuprofen were formulated employing potato starch, Primogel, microcrystalline cellulose (MCC) and pregelatimised starch (PGS) and the tablets were evaluated for content of active ingredient, hardness, friability, disintegration time, uniformity of dispersion and dissolution rate. Tablets formulated employing Primogel as internal and external disintegrant and tablets formulated employing potato starch as internal disintegrant and Primogel and PGS as external disintegrants fulfilled all the official and other requirements of dispersible tablets. These tablets also gave rapid and higher dissolution rate then the formulated as well as conventional (commercial) tablets. The dissolution of ibuprofen from the tablets followed first order kinetics. The dissolution rate of ibuprofen, a poorly soluble drug could be increased by formulating it as dispersible tablets.