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Abstract

Formulation And Evaluation Of Isopropyl Antipyrine Oral Suspensions

Author(s): S Mahesh, S Narasimha Murthy, K. L. K Paranjothy, N. G Nanjundaswamy

Attempts were made in the present investigation to evolve a physico-chemically stable, elegant and palalable isopropyl antipyrine oral suspension using suspending agents like sodium carboxy methyl cellulose [Sod. CMC], veegum alone and combination of sodium CMC and microcrystalline cellulose [MCC] in varying proportions. The suspensions were subjected to evaluation and accelerated stability studies have been carried out on a few select formulations. The best formulation was found to have a shelf life of about 2.5 years and bioequivalence studies revealed comparible pharmacokinetic parameters as that of the marketed tablet.