Formulation And Evaluation Of Ketoconazole Niosomes
Ketoconazole niosomes were prepared by ether injection technique using surfactant (Tween 40 or 80), cholesterol and drug in five different ratios by weight, 1:1:1, 1.5:1:1, 2:1:1, 2.5:1:1 and 3:1:1. The niosomes were characterized for size, shape, entrapment efficiency and in vitro drug release (by exhaustive dialysis). The formulations were also tested for in vitro (cup-plate method) and in vivo antifungal activity (in rabbits) and compared with free ketoconazole. The results of the present study indicate that niosomes have the potential to reduce the therapeutic dose of ketoconazole by improving its performance.