All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Formulation and evaluation of nitrendipine buccal films

Author(s): M Nappinnai, R Chandanbala, R Balaijirajan
Department of Pharmaceutics, C. L. Baid Mehta College of Pharmacy, Jyothi Nagar, Chennai-600 096, India

Correspondence Address:
M Nappinnai Department of Pharmaceutics, C. L. Baid Mehta College of Pharmacy, Jyothi Nagar, Chennai-600 096, India India E-mail: [email protected]


A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 and carbopol-934P were used for film fabrication. The films were evaluated for their weight, thickness, percentage moisture absorbed and lost, surface pH, folding endurance, drug content uniformity, In vitro residence time, In vitro release and ex vivo permeation. Based on the evaluation of these results, it was concluded that buccal films made of hydroxylpropylcellulose and sodium carboxymethylcellulose (5±2% w/v; F-4), which showed moderate drug release (50% w/w at the end of 2 h) and satisfactory film characteristics could be selected as the best among the formulations studied.



Share this