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Abstract

Formulation Of Choline Salicylate As Lozenge Tablet For Improved Delivery To Oral Cavity

Author(s): Manoj Kumar, Roop K Khar, S. P Agarwal, Alka Ahuja

Choline salicylate was formulated as a lozenge tablet to provide prolonged relief from pain associated with mouth ulcers. The lozenges were prepared using mannitol as base and gelatin dispersion as binder. The composition of optimized tablet was; choline salicylate, 20 mg; HPMC-E15, 20 mg; CP 934P, 4 mg; gelatin, 50 mg; mannitol, 896.5 mg; magnesium stearate, 5 mg; cetrimide, 0.5 mg; aspartame, 0.4 mg and flavour. Dissolution studies showed 95% release of drug in 65 min. In mouth, salivary concentration was 130.00 μg/ml-7. The hardness of tablet was 10.44 kg.cmq and they were non-gritty and had good mouthfeel, taste and comfort. Lozenge tablet formulation can provide an attractive alternative formulation in the alleviation of pain in recurrent aphthous mucosal ulcers.