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Abstract

Gas Chromatographic Determination Of Clopidogrel From Tablet Dosage Forms

Author(s): N. S Kamble, A Venkatachalam

A gas chromatographic method was developed for the determination of clopidogrel in its tablet form. The method involves use of a DB-17 capillary column. Column is of 30 m length, 0.25 mm i.d. and 0.25 μ film thickness, and hydrogen as a carrier gas with the flow rate of 2.0 ml/min. Oven temperature was maintained at 250° for 8 min. Split type of injector and flame ionization detector was used. The retention time of clopidogrel and dioctyl phthalate (internal standard ) was 4.1 min and 3.2 min, respectively. Linearity for the clopidogrel was in the range of 0.5 to 5.0 mg/ml. Percentage recovery obtained was 99.89.The proposed method is accurate, precise and rapid for the estimation of clopidogrel.