All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Haematopoietic activity of Asteracantha longifolia on cyclophosphamide-induced bone marrow suppression

Author(s): RS Pawar, AP Jain, SK Kashaw, AK Singhai
Division of Pharmacognosy and Phytochemistry, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India

Correspondence Address:
A K Singhai Division of Pharmacognosy and Phytochemistry, Department of Pharmaceutical Sciences, Dr. H. S. Gour University, Sagar-470 003, India E-mail: [email protected]


Chloroform extract of the leaves of Asteracantha longifolia at different doses (250 and 500 mg/kg body weight) was examined on anaemic albino rat for certain haematological parameters like erythrocyte count, leukocyte count, and haemoglobin count. Chloroform extract was found to significantly (b,b1,b2,b3P <0.05) improve erythrocyte and haemoglobin count on the 22nd day (d) after 7 d of continuous cyclophosphamide (3 mg/kg body weight) treatment. Treatment with chloroform extract along with cyclophosphamide was found to significantly ( P <0.001) increase the bone marrow cellularity (11.5×106) as compared to cyclophosphamide alone treated group (6.2×106). Administration of extract increased the number of a-esterase positive cells (1062/4000) in the bone marrow of cyclophosphamide-treated animals, compared to the cyclophosphamide alone treated group (650/4000). The major activity of A. longifolia may be stimulation of stem cell proliferation. The observations that A. longifolia could reduce the cyclophosphamide-induced toxicity may indicate its usefulness in cancer therapy.



Share this