All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

High performance liquid chromatographic determination of aspirin and clopidogrel in tablets

Author(s): M Gandhimathi, TK Ravi
Department of Pharmaceutical Analysis, Sri Ramakrishna College of Pharmacy, Coimbatore-641 044, India

Correspondence Address:
M Gandhimathi Department of Pharmaceutical Analysis, Sri Ramakrishna College of Pharmacy, Coimbatore-641 044 India E-mail: [email protected]


A reverse phase high performance liquid chromatographic method to determine aspirin and clopidogrel in combined dosage form is proposed. The chromatographic resolution of aspirin and clopidogrel was obtained in a mobile phase consisting of 0.1% v/v triethylamine (pH 4.0):acetonitrile in the ratio 25:75% (v/v) in an isocratic elution. A detection wavelength of 225 nm and flow rate of 1 ml/min was used in the study. Nimesulide (20 µg/ml) was used as an internal standard. The system suitability procedures as precision, accuracy, LOD, LOQ, number of theoretical plates and tailing factor were studied.



Share this