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Abstract

HPTLC method for the simultaneous estimation of Tizanidine and Rofecoxib in tablets

Author(s): TK Ravi, M Gandhimathi, KR Sireesha, Shaise Jacob
Department of pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical sciences, Coimbatore-641 044, India

Correspondence Address:
M Gandhimathi Department of pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical sciences, Coimbatore-641 044 India E-mail: [email protected]


A new simple, accurate and precise HPTLC method has been developed for the simultaneous estimation of tizanidine and rofecoxib in tablet formulation. In this method, standard and sample solutions of tizanidine and rofecoxib were applied on precoated silica gel G 60 F254 TLC plate, and developed using n- butyl acetate: formic acid: chloroform (6:4:2 v/v/v), as mobile phase. The drugs on plate were scanned at 315 nm. The dynamic linearity range was 2-10 mg/spot for tizanidine and 16-80 mg/spot for rofecoxib. The method was validated for precision, accuracy, and reproducibility.



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