In vitro and in vivo Evaluation of Flavonoids from Heliotropium ellipticum Exudate for Antioxidant, Antineoplastic and Cytotoxic Activities II
Institute of Biotechnology, Amity University Rajasthan, Jaipur-303 002, Medicinal Plants Research Laboratory, Department of Botany, University of Rajasthan, Jaipur-302 004, India
Institute of Biotechnology, Amity University Rajasthan, Jaipur-303 002, India, E-mail: [email protected]
Flavonoids are a large group of plant secondary metabolites that occur in various types of fruits and vegetable crops. The present study attempted to isolate and test flavonoids from the Heliotropium ellipticum exudate for antioxidant, antineoplastic and cytotoxic effects. Results obtained revealed that chrysin demonstrated higher DPPH scavenging (297.21±0.36%), reducing power (428.21±0.23%), superoxide anion scavenging (283.59±0.39%) and metal chelating (459.52±0.11%) activities. Chrysin showed greater antioxidant activity in comparison to the ascorbic acid (standard compound). Similarly, it also exhibited high activity against sarcoma 180 (81.90%) and Chinese hamster V79 (37.2±0.67%) cells at different tested concentrations. Results obtained suggested that chrysin could be used as a potent antioxidant, antineoplastic and cytotoxic agent.