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Abstract

Implantable Methotrexate Films Using Poly (E Caprolactone) As Biodegradable Carrier

Author(s): U. V Singh, N Udupa

Biodegradable films of Methotrexate using Poly (E caprolactone) were prepared. The in vitro release was enhanced on incorporation of Poly (glycolic acid). The in vivo degradation of the polymer was faster compared to the in vivo drug release. The histopathological studies showed no deleterious effects at the site of implantation.