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Abstract

Improvement Of Dissolution Rate And Bioavailability Of Piroxicam With Pregelatinized Starch

Author(s): N Rama Rao, K. P. R Chowdary

Piroxicam (PPX) dispersions in pregelatinized starch (PGS) were prepared in different drug and carrier ratios and were characterized by X-ray diffractograms (XRD), differential scanning calorimetry (DSC), differential thermal analysis (DTA) and dissolution studies. Bioavailability studies were conducted on PRX-PGS dispersions and PRX pure drug in healthy human subjects as per cross over randomized block design (RBD). From Time Vs blood concentration data Cmax, Tmax, Ka, AUC and T1/2, were calculated. Higher dissolution rates were noted with dispersions when compared to piroxicam as such. PRX-PGS dispersions also gave fast absorption and higher blood levels of piroxicam when compared to pure drug. All the absorption parameters namely Cmax, percent absorbed In 1 and 2 h, Ka, AUC were higher indicating faster absorption of PRX from dispersions.