Improvement of dissolution rate and bioavailability of piroxicam with Pregelatinized Starch.
KVSR Siddhartha College of Pharmaceutical Sciences, Vijaywada-520010
N R Rao KVSR Siddhartha College of Pharmaceutical Sciences, Vijaywada-520010
Piroxicam (PPX) dispersions in pregelatinized starch (PGS) were prepared in different drug and carrier ratios and were characterized by X-ray diffractograms (XRD), differential scanning calorimetry (DSC), differential thermal analysis (DTA) and dissolution studies. Bioavailability studies were conducted on PRX-PGS dispersions and PRX pure drug in healthy human subjects as per cross over randomized block design (RBD). From Time Vs blood concentration data C(max), T(max), K(a), AUC and T(1/2), were calculated. Higher dissolution rates were noted with dispersions when compatred to piroxicam as suc. PRX-PGS dispersions also gave fast absorption and higher blood levels of piroxicam when compatred to pure drug. All the absorption parameters namely C(max), percent absorbed in 1 and 2h, Ka, AUC were higher indicating faster absorption of PRX from dispersions.