In vitro and in vivo release studies of paracetamol crystals produced by solvent change method. part ll
Goa College of Pharmacy, Panjim, Goa,
K S Shahwan Goa College of Pharmacy, Panjim, Goa
The in vitro dissolution behaviour of paracetamol crystals from their respective tablets showed faster release from those produced by ethanol and propylene glycol. This was in good agreement with the intrinsic in vitro release behaviour reported by us. Such crystals also showed faster in vivo release than the original powder.