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Abstract

In Vitro Cytotoxic Studies Of Mannich Bases Of ?-Diketones

Author(s): R Rajesh, A. A Siddiqui, G. V. S Ramasarma, V Alagarsamy

In vitro cytotoxic activity of some 2-(N-aryl/heteroaryl aminomethyl)-1,3-diphenyl/1-phenyl-3-(3- nitrophenyl)/1-phenyl-3-(pyridin-3-yl)propan-1,3-diones were determined by adopting three methods (Trypan blue dye exclusion, Lowry, MTT, 3-(4,5-dimethyl thiazol-2-y1)-2,5-diphenyl tetrazo- lium bromide assay) using HEp-2 cell cultures. Among the compounds tested the compound Vlll was found to be superior in its cytotoxicity in all the three methods.