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Abstract

In vitro dissolution profile of sustained release dosage form of chlorpheniramine maleate

Author(s): SM Sista, SK Das, BK Gupta
Divn. of Pharmaceutics, Dept. of Pharmacy, Jadavpur University, Calcutta 700 032

Correspondence Address:
S M Sista Divn. of Pharmaceutics, Dept. of Pharmacy, Jadavpur University, Calcutta 700 032

In vitro release of chlorpheniramine maleate (CPM) from formaldehyde rigidized gelatin micropellets was studied. The dissolution profile correlated well with the requirements for drug release from sustained release dosage forms. The resulting formulations significantly prolong the drug release and not more than 41 percent of the embedded drug released within the first 30 minutes of in vitro dissolution study.