In Vitro Permeation Of Ionized And Unionized Diclofenac : Comparison Of Chitosan Membranes With Rat Skin
To predict permeability of drugs through the skin chitosan membranes have been formulated. The in vitro permeability of ionized and unionized diclofenac through chitosan membranes has been compared with that of dorsal skin of Wistar rats. The chitosan membranes were prepared by cast drying to achieve thickness of hairless-dorsal-skin of Wistar rats. The thickness of chitosan membrane varied with change in concentration of chitosan and sodium tripolyphosphate. The chitosan membrane has been observed to mimic the flux of ionized and unionized diclofenac through rat skin. Chitosan membranes are easy to prepare with controlled composition and reproducibility.