Inclusion Complexation Of Rofecoxib With Dimethyl ?-Cyclodextrin
An attempt has been made to enhance solubility and dissolution of rofecoxib by complexation using dimethyl Î²-cyclodextrin. Complexes were prepared by physical mixture, kneading and spray drying methods. The prepared complexes were evaluated by Fourier transform infra-red spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy. Release profile of the drug from the complexes were studied in pH 1.2 and pH 7.4 and it was found that the marketed preparation showed lesser release characteristics as compared to the complex prepared by kneading method.