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Abstract

Increased gastro-intestinal absorption of griseofulvin from w/o/w emulsions.

Author(s): CO Onyeji, JA Omotosho, FA Ogunbona
Dept. of Pharmaceutical Chemistry,

Correspondence Address:
C O Onyeji Dept. of Pharmaceutical Chemistry

The extent of a absorption of grissofulvin (500 mg) from oil-in-water (O/W), water-in-oil-in-water (w/o/w)emulsions and tablet dosage forms were determined and compared following oral administration of each of the dosage forms, in a crossover fashion, to 8 healthy volunteers. The absorption characteristics were assessed by measuring the urinary excretion of the major metabolite of griseofulvin (6-desmethylgriseosulvin). From these results, it is suggested that the administration of griseofulvin in the W/O/W emulsion may lead to the enhancement of therapeutic efficacy of the drug in man.