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Abstract

Indirect Potentiometric Titration Of Isoniazid In Pharmaceutical Dosage Forms Using A Copper Based Mercury Film Electrode

Author(s): P Riyazuddin, M. M Abdul Kamal Nazer

A simple and rapid potentiometric method for the estimation of isoniazid in dosage forms was developed. The method was based on treating isoniazid with iodine and titration of the iodide produced equivalent to isoniazid with silver nitrate using a copper based mercury film electrode (CBMFE) as an indicator electrode. No interference was caused by other excipients present in dosage forms. The results of the proposed method and British Pharmacopoeia method were compared using F and t statistical tests of significance.