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Abstract

Inflammation And Novel Therapeutic Approaches For Its Management

Author(s): D Hari Krishna, M Sripal Reddy, K Rajnarayana, D.R Krishna, M.C Prabhakar

Inflammation is a biological response to a series of chemical reactions whose major function is protection from infection and the resolution of tissue damage caused by injury. There are several mediators released during the process of inflammation. Activation of phospholipase-A2 (PLA2) family is a key step in the production of precursors in biosynthesis of inflammatory lipid rnediators. Platelet activating factor, cyclooxygenase-2, leukotrienes, nerve growth factor, inducible nitric oxide synthase, bradykinins, adhesion molecules, nuclear factor-kB and cytokines are also important mediators for inflammation. There are several agents, which inhibit the endogenous mediators that can be used for the treatment of inflammation. Apoptosis is another important mechanism, where several agents that act by different mechanisms of action can treat the inflammation.