Abstract

Influence of food on the bioavailability of nitrofurantoin.

Author(s): AA Ali, AS Gorashi, YM Rao, Madhusudan Rao Y
Dept. of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Sudan,

Correspondence Address:
A A Ali Dept. of Pharmaceutics, Faculty of Pharmacy, University of Khartoum, Sudan

The bioavailability of microcrystalline tablet and macrocrystalline capsule forms of nitrofurantoin increased when administered with food. In both fasting and nonfasting subjects the maximum excretion rate of macrocrystalline in fasting state only. Enhanced absorption of nitrofurantoin with food was attributed to the greater motility of small intestine and accelerated gastric emptying with the diet used.