Abstract
Influence Of Hydroxypropyl b-Cyciodextrin On Dissolution Of Piroxicam And On Irritation To Stomach Of Rats Upon Oral Administration
Solid dispersions of hydroxpropyl b- cyclodextrin (HPB), a highly water soluble derivative of b- cyclodextrin and piroxicam (PRX) were prepared by kneading, co-evoporation and freeze-drying. X-ray diffraction, differential scanning calorimetry, IR-spectral studies and thin layer chromatography were used to characterise the solid dispersions and also to study the possibility of complexation of the drug with HPB. A marked difference in characteristics of dispersions was observed due to their methods of preparation. The dissolution of PRX from the solid dispersion was studied by the dispersed powder technique and also as per USP 1990 which was found to have improved considerably over that of the pure drug alone. Coevaporated and freeze dried dispersions caused significant reduction in irritation to stomach mucosa of rats upon oral administration.
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