Interactions of Acephate, Glyphosate, Monocrotophos and Phorate with Bovine Serum Albumin
Regional Ayurveda Research Institute for Drug Development, Amkhoh, Gwalior-474 009, 1Department of Biotechnology, Lovely Professional University, Punjab-144 111, India
Regional Ayurveda Research Institute for Drug Development, Amkhoh, Gwalior-474 009, India, E-mail: [email protected]
Binding of pesticides to serum albumin significantly influence their absorption, metabolism, distribution and excretion. In the present study, interactions of acephate, glyphosate, monocrotophos and phorate with bovine serum albumin were explored employing the UV/Vis and Fourier-transform infrared spectroscopy methods. The observed values of binding constant for titled pesticides were. phorate (1.85×107 M-1)>acephate (3.93×104 M-1)>glyphosate (1.31×104 M-1)>monocrotophos (1.12×104 M-1). Results have shown that out of four pesticides, phorate could show strong interactions with bovine serum albumin.