Investigation Of The Antidarrhoeal Activity Of Holarrhena Antidysenterica
Holarrhena antidysenterica (L)-Apocyanaceae, well known for its antidiarrhoeal activity was studied for its effect on diarrhoeagenic Escherichia coli. Different dilutions of the decoction of the plant were assayed for its effect on the adherence and toxin production of 2 groups of E.coli- enteropathogenic (EPEC) and enterotoxigenic (ETEC.) Adherence per se was not affected though disruption of the characteristic 'microcolonies' of EPEC on HEp-2 cell line was observed. The decoction was more effective in inhibiting stable toxin production as compared with labile toxin production.