Isolation and Evaluation of Binding property of Lannea coromandelica gum
Division of Pharmaceutical Technology, Andhra University College of Pharmaceutical Sciences, Visakhapatnam-530 003, India
D. Lohithasu Division of Pharmaceutical Technology, Andhra University College of Pharmaceutical Sciences, Visakhapatnam-530 003, India E-mail: [email protected]
The objective of this present study was to investigate binder property of Lannea coromandelica in tablet formulations and its comparative binding property with povidone as standard binder. All the eight tablet batches (F-1 to F-8) were prepared by wet granulation technique. Microcrystalline cellulose (Prosolv SM) as diluent, diclofenac sodium as model drug using 4, 6, 8 and 10% of L. coromandelica gum used as a novel binder, magnesium stearate used as an antiadherent and talc used as lubricant. Micromeritic properties of granules such as bulk density, tapped density, compressibility index, hausner’s ratio, angle of repose as well as physical parameters of the compressed tablets like hardness, friability, thickness and disintegration time were determined and found to be satisfactory. The Fourier transform infrared spectroscopic analysis showed that the tablet formulation containing L. coromandelica gum is compatible with the drug and other excipients, which are used in the tablet formulation. Thus, concluded that L. coromandelica gum has role as a potential binder in tablets formulations. The in vitro drug release profile concluded that tablets formulations containing L. coromandelica gum 20 mg/200 mg of total weight of tablet as binder showed better results as compared to povidone as standard binder.