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Abstract

Mathcad : A Tool For Designing Sustained Release Formulations

Author(s): D. A Shah, Yamini Shah, S Gupta

Although sustained release drug delivery systems were introduced in the market at the beginning of 1960s it became popular only after 1970. In order to maintain blood levels of a drug within the safe margin, calculated doses of the drug need to be given at different time intervals or one preprogrammed drug delivery system need to be given which will release drug at a rate and for a period as per the therapeutic need.1 Fig.1 represents plasma drug levels versus time curve for a drug administered as conventional dosage form, (I), and sustained release dosage form (II)2.