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Abstract

Microencapsulation Of Verapamil Hydrochloride By Ionotropic Gelation Technique

Author(s): P. M Dandagi, F. V Manvi, A. P Gadad, V. S Mastiholimath, M. B Patil, V Balamuralidhara

Micropellets of verapamil hydrochloride were formulated by ionotropic gelation technique using sodium alginate, hydroxypropylmethylcellulose and hydroxypropylcellulose. Prepared micropellets were evaluated for flow behavior, drug entrapment efficiency, in vitro dissolution and stability ' studies, including scanning electron microscopy and optical microscopy. Of the nine formulations prepared and evaluated formulations F3, F6 and F9 were found to show satisfactory results. The release of the drug from the micropellets was found to be following non-Fickian diffusion; Drug diffusion coefficient and correlation coefficient were also assessed using various mathematical models. From the study it was concluded that, prolonged release verapamil hydrochloride micropellets could be achieved with success using ionotropic gelation technique.