Microwave Assisted Synthesis, AntiHIV, And AntiYFV Activities Of Schiff Bases Of N-HY-Droxy-N1-Aminoguanidine Tosylate
The microwave-assisted syntheses of N-hydroxy-N1-aminoguanidines (S1-S8) starting from thiosemicarbazide are reported herein. These derivatives were evaluated against infection by the human immunodeficiency virus type-1 using human T4 lymphocyte cell line and yellow fever virus strain 17D activity in Vero cells. Compound 1-(4'-chlorobenzylidene) amino-3-hydroxy guanidine (S3) showed maximum percentage protection of 43.68% against HIV-1 induced cytopathogenicity. Compound S3 was also found to be the most active compound against YFV with EC50 of 2.5 Î¼M, and CC50 of more than 100 Î¼M when compared to ribavirin.