All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Microwave-Assisted Synthesis, And AntiHIV Activity Of 2,3-Dairyl-1,3-Thiazolidin-4-Ones

Author(s): D Sriram, P Yogeeswari, T. G Ashok Kumar

Several 1,3-thaizolidin-4-ones bearing variously substituted diaryl ring at C-2 and N-3 positions have been synthesized utilizing microwave irradiation and evaluated for their antiHlV and antiYFV activities. The results of the in vitro antiHlV evaluation showed that compound DS13 proved to be an effective inhibitor of HIV-1 replication with EC50 of 10 μM, CC50 of 120 μM and percentage protection of 104%.