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Abstract

Modification Of Lactose For Direct Compression - I

Author(s): A. B Rao, A. N Misra

An attempt was made to provide cheaper, indigenous, directly compressible lactose by thermal modification of lactose I.P. The modified lactose (Thermally modified lactose, TML) was characterised for physico-chemical properties and flow behaviour and the results compared with those of Marketed directly compressible lactose (MDL). The direct compressibility of TML and MDL was also evaluated by compression on a rotary tablet compression machine. Results indicated TML to be a promising directly compressible excipient which can replace imported directly compressible lactose.