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Abstract

Modification Of Lactose For Direct Compression-II

Author(s): A. B Rao, A. N Misra

An attempt was made to provide cheaper, indigenous, directly compressible lactose by spray drying a slurry of lactose I.P. The modified lactose (spray-dried lactose, SDL) was characterised by evaluating physico-chemical properties and flow behaviour and the results obtained were compared with those for marketed directly compressible lactose (MDL). The direct compressibility of SDL and MDL was also evaluated by compression on a rotary tablet compression machine. Results indicated that SDL has the potential to be used as a directly compressible excipient which can replace imported directly compressible lactose.