Nanoemulsion based intranasal delivery of antimigraine drugs for nose to brain targeting
1 C. U. Shah College of Pharmacy, S. N. D. T. Women's University, Juhu Campus, Santacruz (West), Mumbai-400 049, India 2 Bombay Veterinary College, Parel, Mumbai-400 012, India 3 Department of Nuclear Medicine, Bombay veterinary College, Parel, Mumbai-400 012, India
A N Bajaj C. U. Shah College of Pharmacy, S. N. D. T. Women's University, Juhu Campus, Santacruz (West), Mumbai-400 049 India [email protected]
The objective of this study was to develop intranasal nanoemulsion and gel formulations for rizatriptan benzoate for prolonged action. Nanoemulsion formulations were prepared by constructing pseudo-ternary phase diagrams using lipophilic and hydrophilic surfactants and water. Various mucoadhesive agents were tried out to form thermo-triggered mucoadhesive nanoemulsions. Mucoadhesive gel formulations of rizatriptan were prepared using different ratios of HPMC and Carbopol 980. Comparative evaluation of intranasal nanoemulsions and intranasal mucoadhesive gels indicated that greater brain-targeting could be achieved with nanoemulsions.