Nanoparticular Antineoplastic Drug Delivery System Using Bovine Serum Albumin
Targeted drug delivery is an effective means in cancer chemotherapy. Nanoparticulation is one of the useful means for targeted drug delivery. In the present investigation a broad spectrum anticancer drug methotrexate is nanoparticulated in a foreign protein bovine serum albumin. The particle size distribution was measured using a transmission electron microscope. Two sets of nanoparticles were prepared by varying Protein: drug ratio. The pattern of drug release from the nanoparticles were observed in pH 7.4 at 37o. A non-fickian type of release was observed from both sets.