Nasal mucoadhesive in situ gel of ondansetron hydrochloride
Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018, India
A V Bhalerao Padm. Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411 018 India [email protected]
Ondansetron is a serotonin receptor antagonist used in the management of nausea and vomiting that is associated with cancer chemotherapy. There is a need for intranasal delivery due to poor bioavailability of drug because of first pass effect. The objective of this study was to develop an intranasal delivery system of ondansetron hydrochloride using thermo-sensitive polymer PF127 and mucoadhesive polymer hydroxypropylcellulose. Due to increase in bioadhesive polymer concentration, there was increase in bioadhesion strength, at the same time there was decrease in the spredability. An in vitro diffusion study revealed that viscosity of the vehicle has an influence on drug. The release of ondansetron hydrochloride from the gel matrix showed diffusion- controlled.