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Abstract

New spectrophotometric determination of Raloxifene hydrochloride in tablets

Author(s): DC Pavithra, Lakshmi Sivasubramanian
Department of Chemistry, Pharmaceutical Chemistry Unit, Vellore Institute of Technology, Deemed University, Vellore-632 014, India

Correspondence Address:
Lakshmi Sivasubramanian Department of Chemistry, Pharmaceutical Chemistry Unit, Vellore Institute of Technology, Deemed University, Vellore-632 014 India E-mail: [email protected]


Three new simple and sensitive spectrophotometric methods in UV/Vis region have been developed for the determination of raloxifene hydrochloride in bulk drug and in tablet formulations. Raloxifene hydrochloride exhibited maximum absorbance at 289 nm in methanol (method A) with apparent molar absorptivity of 3.67x104 l/mol.cm and maximum absorbance at 303 nm in 0.1 M sodium hydroxide with apparent molar absorptivity of 3.60x104 l/mol.cm (method B). Third method is based on the formation of red coloured chromogen with ferric nitrate and 1,10-phenanthroline, which showed maximum absorbance at 511 nm with apparent molar absorptivity of 1.06x105 l/mol.cm. Beer′s law was obeyed in the concentration range of 5-25 g/ml for method A and B and in the range of 2-10 µg/ml for method C. Results of all methods were validated statistically and by recovery studies.



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